I have lost count of the number of times I’ve had to say “no sorry, quotas are replica specific so you have to set them on each server”. In Domino v12 quota settings now replicate between servers. They don’t need to be replicas in a cluster, the quota settings (or even if quotas are enabled) are replicated to any other database replica along with other database properties like the ACL. Changing a database quota requires Manager access to the database and (in my testing) the most recent change takes precedence.
If you don’t want to maintain quota settings across replicas you can add the notes.ini command Disable_Repl_Quota=1 which will prevent the instance on that server from replicating out its quota settings.